HOD, Pharmaceutical analysis and QA, Gyana Jyothi College of Pharmacy, Boduppal, Hyderabad
A B S T R A C T
In the present research work gastro retentive floating matrix formulation of Hydrochlorthiazide by using various hydrophilic polymers. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of polymers of various grades of HPMC and guar gum. The formulation blend was subjected to various pre-formulation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations prepared by using Guar gum were unable to produce desired drug release, they were unable to retard drug release up to 12 hours. The formulations prepared with HPMC K 100 M retarded the drug release up to 12 hours in the concentration of 60 mg (F6).The formulations prepared with HPMC K15M were also retarded the drug release for more than 12 hours. Hence they were not considered. The optimized formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation followed Higuchi mechanism of drug release.
Keywords: Hydrochlorthiazide, HPMC polymers, Floating tablets.