Anjali Waghmode*1, P.Jyothi1, P.Neeraja2, K.Someshwar3, Vagdevi Y4, P. Nithin Kumar4
1Geethanjali College of Pharmacy, Cheeryal, , Keesara, R.R. Dist, Telangana
2Assistant Professor, Geethanjali College of Pharmacy, Cheeryal, Keesara, R.R. Dist, Telangana
3Manager, Formulation R&D, KP Labs (A Division of KDPL), Kothapet, Hyderabad
4Research Assistant, KP Labs (A Division of KDPL), Kothapet, Hyderabad
A B S T R A C T
Atomoxetine is a norepinephrine (noradrenaline) reuptake inhibitor; atomoxetine is approved for use in children, adolescents, and adults. The initial therapeutic effects of atomoxetine usually take 2 to 4 weeks to be become apparent. A further 2–4 weeks may be required for the full therapeutic effects to be seen. Its efficacy may be less than that of stimulant medications. The object of the present work is preparing floating tablets in controlled fashion. The gas generating agent sodium bicarbonate was added in different concentrations with varying amount of retardation polymers. Different grades of HPMC polymers HPMC K4M, K15M & K100M were used as retarding polymers. The formulation blend was evaluated for various physicochemical properties and all the parameters were found to be within limits. The formulations F1-F12 were formulated and evaluated for various quality control parameters. All the formulations were passed the tests and the results were within limits. From the dissolution data, it was evident that formulation F10 was found to be best with maximum % drug release of 96.10% and floating time of 10 hours.
Keywords: Atomoxetine, HPMCK4M, HPMCK15M, HPMCK100M & Floating tablets.