Formulation and In-vitro Evaluation Fast Dissolving Tablets Ramosetran Hydrochloride using Co-Processed Super Disintegrating Technology

G. Vijaya Reddy*¹, M. Divya¹, M. Kiranmai¹, G. Kalpana Devi^2
1Sai Pranavi College of Pharmacy, Keesara, R.R. Dist., Telangana, India
²Assistant Professor, Sai Pranavi College of Pharmacy, Keesara, R.R. Dist., Telangana, India

A B S T R A C T
In the present work, an attempt has been made to develop fast disintegrating tablets of Ramosetron hydrochloride. Novel method of co processed super disintegrates technology was employed to formulate the tablets. All the formulations were prepared by direct compression method. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations, F14 formulation showed maximum drug release i.e., 99.3% in 4 min hence it is considered as optimized formulation. The F14 formulation contains CP5 as super disintegrate in the concentration of 30 mg. (CP 5 contains Vivasole and polyplasdone XL in 3:1 ratio).
Keywords: Ramosetron hydrochloride, Co processed super disintegrates, Vivasole and polyplasdone  XL.