Friday , 23 August 2019

Formulation and In-vitro Evalaution of Repaglinide Controlled Release Tablets

Pravalika Segonda*, Dr. P Mani Chandrika, Safura, Saleha Sultana, Sameera Gousher, Samreen Fathima, Sameena Begum.
Bojjam Narasimhulu Pharmacy College for Women, Vinay Nagar, Saidabad, Hyderabad, Telangana, India.

A B S T R A C T
The purpose of present research work was to prepare and evaluate the controlled release tablets of Repaglinide. Direct compression method was used to prepare the tablets using different polymers like Eudragit S-100, Eudragit RSPO, Eudragit RLPO, Eudragit L-100, HPMC K4M and HPMC K15M. Twelve formulations (F1-F12) were prepared by varying the amount of polymers. The prepared tablets were evaluated for both pre-compression and post-compression parameters. Among all the formulation, F11 is considered as ideal formulation which exhibited 97.82% drug release in 12 hours. The results of dissolution data were fitted to various drug release kinetics and the optimized formulation F11 follows Higuchi’s kinetics with R2 value 0.99 and diffusion exponent values (n) of all repaglinide controlled release tablets were found to be 0.35-0.50 which indicates fickian diffusion.
Keywords: Repaglinide, Eudragit S-100, Eudragit RSPO, Eudragit RLPO, Eudragit L-100, HPMC K4M and HPMC K15M, Direct compression method.

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