Formulation and Evaluation of Transdermal Patches of Carbamazepine

Dronamraju. Nirmala Kumari*, Kondru. Lalitha, Kinnera. Poosha, Sureddy. Lakshmi Prasanna, SK. Moulabi
Department of Pharmaceutics, Mother Teresa Pharmacy College, Sathupally, Khammam, Telangana, India

A B S T R A C T
The aim of the present investigation was to prepare Carbamazepine Transdermal patches of matrix type and membrane controlled type using the HPMC, NaCMC and PVP in different ratios by the solvent casting method. The systems were evaluated for various in vitro parameters like Thickness, Folding endurance, Moisture content, Moisture uptake, Drug content, Drug permeation. The drug- Polymer interactions were studied by FTIR. And in vivo studies like Skin irritation studies. The Drug content of the patches was found to be more than 95%, In-vitro permeation studies were performed by using chein diffusion cells for 6 hrs.
Keywords: Transdermal drug delivery, Matrix patch, Membrane controlled Patch, Carbamazepine, PVP, In-vitro and In vivo skin permeation studies.