Monday , 27 March 2017

Formulation and Evaluation of Topical Proniosomal Gel of an Anti Fungal Drug-Itraconazole

Srividhya Vardhani CH*, Nirosha M
Department of Pharmaceutics, Oil Technological and Pharmaceutical Research Institute, JNTUA Ananthapuramu, India

A B S T R A C T
Proniosomal gels are the liquid crystalline compact Niosomal hybrids that can be converted into niosomes immediately upon hydration or used as such in the topical/ transdermal applications. Itraconazole is an Anti fungal drug which on Oral administration has Bioavailability of 55% only because of first pass hepatic metabolism. In order to bypass the First pass effect and also to decrease other Oral route side effects like Dry mouth, Nausea, Vomiting etc they can be formulated into Proniosomal gels for an effective Transdermal drug delivery. The Present study was aimed at preparing twelve formulations of Topical Proniosomal gels with different concentrations of surfactants and cholesterol. All the prepared formulations were evaluated for Physical appearance, pH, Vesicle size analysis, Vesicle shape and surface characteristics, % Entrapment efficiency, In-vitro drug release studies and Stability studies. Among all the formulations F4 was found to exhibit optimum results for all the evaluation tests and In vitro drug release was found to be 91.9% at the end of 9th hour. The drug release of all formulations followed zero order kinetics on fitting the drug release data to various kinetic models. Thus Proniosomal gels are the promising approach for Itraconazole to overcome the gastrointestinal side effects and to increase the drug bioavailability.
Keywords: Itraconazole, Proniosomal gels, Coacervation phase separation method, Non ionic surfactants, Cholesterol.

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