S. Sai Vikas1*, M. Nirosha2, T. Pragna3, D. Shakeer4, L.Chandana5, D. Tarun6
Department of Pharmaceutics, JNTUA-Oil Technological & Pharmaceutical Research Institute, Ananthapuramu, AP, India.
A B S T R A C T
Fast disintegrating oral systems are designed to provide rapid onset of action within a minute without need of water, swallowing or chewing. Telmisartan is an anti-hypertensive agent which is having biological half life of 24 hrs. In order to attain immediate action, Telmisartan oral films were prepared by Solvent casting method using various combinations of polymers and plasticizers. For the present study HPMC E5, Sodium alginate, Gelatin and Maltodextrin were used as polymers and propylene glycol and glycerine were used as plasticizers. Empty films were prepared and evaluated for various physico-chemical properties for selection of suitable polymer and plasticizer combination. Then, drug loaded films were prepared with five selected optimized formulations and evaluated for various parameters. All five formulations are colourless, homogenous and transparent. Among all the formulations , HPMC E5 and propylene glycol combination films showed good results for all the evaluation parameters. Among the five formulations FT1 gave acceptable results like disintegration time of 32 sec which is less than 1 min, dissolving time of 44 sec with maximum drug content of 97.5±0.31 and in-vitro drug release was found to be 98.53% within 10 min. Thus, Telmisartan oral disintegrating films containing HPMC E5 will be a promising drug delivery for immediate drug release in the treatment of hypertension.
Keywords: Oral disintegrating films, Telmisartan, Disintegration time, Sodium alginate, HPMC E5.