Formulation and Evaluation of Sustained Release Tablets of Buclizine Hydrochloride

Aukula Monica, Venugopalaiah P*, K. Gnana Prakash, M. Gobinath, Masaram Saritha
Department of Pharmaceutics, Ratnam Institute of Pharmacy, SPSR Nellore, Andhra Pradesh, India-524346

A B S T R A C T
Sustained release, sustained action, controlled release, extended action, timed release, depot and repository dosage forms are terms used to identify drug therapy systems that are designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. In the present study an attempt was made to prepare sustained release tablets of buclizine hydrochloride. Buclizine hydrochloride is anti-histaminic agent or anti emetic drug and used to prevent to treat nausea, vomiting and dizziness caused by motion sickness with less halflife and bioavailability. To maintain the therapeutic drug concentration in systemic circulation for longer time and to improve bioavailability, nine formulations of buclizine hydrochloride (F1 to F9) were prepared by wet granulation method using different polymers like HPMC and Ethyl cellulose in varying ratios. All the formulations were evaluated for various physicochemical properties and found to be within the limits, in-vitro dissolution studies indicated that F9 formulation shows better drug release and the mechanism of drug release follows zero order with non-fickian diffusion transport.
Keywords: Sustained release, Anti-Histaminic agent, buclizine hydrochloride, In-vitro dissolution