FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLET OF TAPENTADOL

ABOUT AUTHOR
Asija Rajesh*, Rathi Harish, Asija Sangeeta
Department of Pharmaceutics,
Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, India.
Email: [email protected], [email protected]

ABSTRACT
The objective of the present study was to develop sustained release tablets of Tapentadol (250mg) by wet granulation using various grades of hydrophilic polymer like Hydroxy propyl methyl cellulose K100M and Hydroxy propyl methyl cellulose 5cps or combination of both. The drug excipient mixtures were subjected to preformulation studies. The tablets were subjected to physicochemical studies, in- vitro drug release, and kinetic studies. FTIR studies shown there was no interaction between drug and polymer. The physicochemical properties of tablets were found within the limits. Tapentadol is a centrally acting analgesic that exerts its pharmacological effects primarily by binding to mu-opioid receptors.. It has plasma half-life of 4-6 hrs and 32%  bioavailability. The drug release from optimized formulations was extended for a period of 24 hrs. The kinetic treatment of selected formulation (F3) showed that the release of drug follows zero order models. Results of the present study indicated the suitability of hydrophilic polymers in the preparation of matrix based sustained release formulation of Tapentadol.
Key words: Tapentadol, Zero order models, Sustained release, Wet granulation, Hydroxy Propyl Methyl Cellulose K-100M