P. Venugopalaiah1, D. Sravanthi1, Pasupuleti Naresh1, R. Dinesh2
1Ratnam Institute of Pharmacy, Pidathapolur, Muthukur (M), Nellore, Andhra Pradesh, India-524346
2Swathi College of Pharmacy, Venkatachalem, Nellore, A.P, India
A B S T R A C T
The main research work is to formulate and evaluate the sustained release Matrix tablets of Felodipine as a model drug by using polymer (HPMC K100LV, HPMC E15LV), Solubulizing agent (Polysorbate 80), microcrystalline cellulose 114, colloidal silicon dioxide, magnesium stearate. This can be done at achive better therapeutic success compared to conventional dosage form of the same drug. The sustained release matrix tablets were prepared by Wet granulation method. In the drug excipient interaction study, it was found that Felodipine was having compatibility with all the excipients used in the formulation. Active drug blended with individual excipients taken in 1:1 ratio. It was filled in closed vials and placed in stability chambers at as 25°C+2oC at 60%+5%RH, 35°C+2oC at 65%+5%RH and 40°C+2oCRH at 75%+5%RH. The FTIR Studies was done hence there is no compatibility in the formulation. The micrometric properties such as angle of repose, Hausner’s ratio, carr’s index were calculated. The obtained value angle of repose (θ) ranges between 28.39-30.46, Hausner’s ratio below 1.25 and carr’s index below 20 indicating good flow properties. The tablets of different formulations were subjected to various evaluation tests such as weight variation, friability, hardness and content-uniformity. The weight variation and friability was less than 4% and 0.7% respectively. The uniformity in drug content was found among different batches of the tablets and the drug content was more than 95%. In Vitro dissolution studies were performed for all the formulations using USPII tablet dissolution tester employing basket type at 100rpm using 500ml of 1% (w/v) polysorbate 80 as dissolution medium the samples withdrawn were analyzed by using HPLC. The stability studies was performed at selected formulations i.e. F5 at 25°C+2oC at 60%+5%RH, 35°C+2oC at 65%+5%RH and 40°C+2oCRH at 75%+5%RH. For 3 months. At the interval of 1 month the formulations were checked for physical appearance, drug content, hardness and friability etc. there was no physical change has been observed in the formulations.
Keywords: Sustained release, Matrix tablets, Felodipine, In-Vitro dissolution.