Ch. Srilatha1, K. Sindhu1*, Dr. M. Ravi Kumar1, Dr. K. Someshwar2
1Geetanjali College of Pharmacy, Keesara, Rangareddy, Telangana, India
2Manager, Formulation R&D, Karthikeya Drugs and Pharmaceuticals Private Limited, Kothapet, Hyderabad.
A B S T R A C T
The purpose of this study is to develop novel a liquisolid technique to enhance the dissolution rate of poorly water soluble drug Quitiapine fumerate. The main components of a liquisolid system are a non volatile solvent, carrier and coating materials and a disintegrant. Liquisolid system refers to the formulations that are formed by conversion of liquid drugs, drug suspensions or drug solution in non-volatile solvents into dry, non adherent, free flowing and compressible powder mixture by blending with suitable carrier and coating materials. Hence the dissolution step, a pre-requisite for drug absorption, is by passed and better bioavailability of poorly soluble drug is achieved. Liquisolid tablets of Quitiapine fumerate are prepared by using PEG as non volatile liquid vehicles and Avicel PH 101, Aerosil as carrier and coating materials respectively. Optimized formulation containing 20% drug in PEG 400, with Avicel 200 as carrier and Aerosil as coating material has shown 98.4% drug release within 20 min .The results are found to be satisifactory.
Keywords: Quitiapine fumerate, Liquisolid compacts, Coating material