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Masaram Saritha, Venugopalaiah P*, K. Gnana Prakash, M. Gobinath, Aukula Monica
Department of Pharmaceutics, Ratnam Institute of Pharmacy, SPSR Nellore, Andhra Pradesh, India-524346
A B S T R A C T
Among the different routes of administration , oral route of administration continues to be most preferred route due to various advantages including ease of administration, avoidance of pain, versatility and most importantly patient compliance. Over the past three decades, ODTs have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance. In the present study oro-dispersible tablets of pantoprazole sodium was developed and optimized to give quick onset of action by rapidly disintegrating in a few seconds without the need of water. Pantoprazole sodium is a proton pump inhibitor which is used in the treatment of peptic ulcer and oral absorption of pantoprazole sodium has bioavailability of 77% with a half life of 1 hour. Nine formulations of pantoprazole sodium ODT (PS-1 to PS-9) was developed by direct compression method using super disintegrants like cross carmellose sodium and sodium starch glycolate in different ratios along with other excipients and evaluated for various physico chemical parameters. All the formulations were subjected to in-vitro drug release studies and among all the formulations, PS-9 containing 4.5% of cross carmellose sodium and 4% sodium starch glycolate showed better drug release of 99.72% at the end of 45 minutes which indicates the best among all the formulations. Results indicate that with increase in the concentration of super disintegrant there is an increase in cumulative percentage drug release. Hence based on the formulation development and their results, direct compression method is more suitable for pantaprazole sodium oral dispersible tablets in terms of palatability, physical and chemical properties.
Keywords: Cross carmellose Sodium, ODT, Sodium starch glycolate, water absorption ratio, Pantaprazole sodium, In-vitro dissolution.
