Formulation and Evaluation of Oral Disintegrating Tablets of Metaprolol

Yatham Rammohan*, P. Suresh, K. Veena. M. Lakshmi Devi, M. Kalavathi, E.Sateesh Kumar
Department of Pharmceutics, Balaji College of Pharmay, Anantapur, AP. India.

A B S T R A C T
Oral disintegrating tablets of Metoprolol  succinate, a  ß1-adrenergic  blocker  and  antihypertensive  agent,  have  been  prepared  from  Sodium Starch Glycolate, Crospovidone, Croscarmellose sodium, Microcrystalline Cellulose, D-Mannitol, Aerosil solution  by direct compression method. In the present study, the oral disintegrating tablets of the drug was prepared using various super disintegrates such as Sodium Starch Glycolate, Crospovidone, Croscarmellose sodium, Microcrystalline Cellulose in various proportions following by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, disintegration time, water absorption ratio and wetting time, in vitro dissolution studies. All the formulation showed rapid disintegration time along with rapid in vitro dissolution. It was concluded that the oral disintegration tablets of the poor soluble drug can be made by direct compression technique using selective super disintegrants showing enhanced dissolution, taste masking and hence better patient compliance and effective therapy.  
Keywords: Metoprolol  succinate, oral disintegrating, Superdisintegrants, Taste masking