Formulation and Evaluation of Omeprozole Magnesium Delayed Release Tablets

Saraswathi M*¹, Uma Sankar K¹, Jayachandra Reddy P^2
1Department of Pharmaceutics, Krishna Teja pharmacy College, Reniguntla Road, Tirupathi-517506, Chittoor, A.P., India
²Department of Pharmaceutical Analysis, Krishna Teja pharmacy College, Reniguntla Road, Tirupathi-517506, Chittoor, A.P., India

A B S T R A C T
The drawback of Omeprazole has complete unstable atmospheres at acidic pH of stomach. Many research studies have completed the solution of above mentioned anti-ulcer drug one technology among of all to provide drug with enteric coated polymers so delay release and make release of drug in proximal small intestine. The sugar spheres will be taken into a FBP and drug will be coated onto the spheres and then they will be sub coated and enteric coated. The enteric coated pellets will be compressed into tablets by direct compression. The tablets will be prepared by using sugar spheres HPMC3cps, HPMC5cps, EL30D5, GMS, and TEC etc. The prepared tablet will be coated by using opadry pink and various parameters evaluated as per standard procedure. FTIR studies will be conducted for optimized formula to prove that the formula will no incompatibility between the drug and excipients. The SEM studies will be conducted to know the surface morphology.
Keywords: Delayed release tablets, Omeprazole, Polymers, Pellets, FTIR, SEM