Heeralal*, P. Shashikala
Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, India.
The objective of the present investigation was to prepare gastro retentive drug delivery systems of Famotodine floating tablets. Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. The drug has low bioavailability (40-45%.), shorter biological half life (2.5-3.5 hours) and it has better solubility in the acidic medium. In the preparation of Famotodine floating tablets sodium bicarbonate was incorporated as a gas generating agent. The tablets were formulated using direct compression technology by employing Accurel®MP1000, Karaya Gum, Chitosan. The prepared tablets exhibited satisfactory physical parameters and good in vitro buoyancy. The in-vitro drug release of floating tablets followed first order kinetics with non fickian diffusion mechanism. The formulations G-VI prepared with Accurel®MP1000, Karaya Gum, Chitosan was evaluated for in vitro floating time, Based on the in vitro evaluation data formulation G-VI was considered as optimized formulation which controlled drug release for upto 12 h. The DSC and FTIR study shows that there is no drug polymer interaction.
Keywords: Non effervescent Floating Tablets, Famotidine HCl, HPMC