Friday , 23 August 2019

Formulation and Evaluation of Nano-emulsion gel of Quercetin

Samriddhi Datri*1, N. Mounika1, I. Prathyusha1, B. Naga Praveen1, V. Lakshmi Prasanna1, G.Priya1, M. Niranjan Babu2
1Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati -517561, A.P, India
2Department of Pharmacognosy, Seven Hills College of Pharmacy, Tirupati -517561, A.P, India.

A B S T R A C T
The aim of the present study was to develop Nano emulsion formulation for transdermal delivery of the Quercetin to enhance bio availability of the drug. Pseudoternary phase diagrams were constructed to obtain the Nano emulsion region. Labrafac was chosen as oil phase, PEG400,Tween 80 were used as surfactant and co surfactant respectively.  EA1 to EA6 different formulations of Quercetin loaded Nano emulsions were prepared successfully by phase titration method and was characterized for particle size, zeta potential, thermodynamic stability study and rheological study.Further, Nano emulsion was incorporated into 1% Carbopol to get a gel for improving convenience in superficial application of drug. EA1 to EA6 different formulations of nanoemulsion gel were prepared and formulations were evaluated for rheological study, Extrudability, swelling index,drug content and invitro drug release studies. Finally it was found that Nano Emulsion EA-6 formulation showed cumulative release as 94%, which shows that Nano emulsion gel has improved absorption and bioavailability.

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