Dr. R. Srinivasan, Sk. Shakir Ahmad*, D. SK. Sarma, M. Geetavani, D. Rajesh Kumar, G. koteswara Rao
Siddhartha Institute of Pharmaceutical Sciences, Jonnalagadda, Narsaraopet, Guntur, Andhra Pradesh, India.
A B S T R A C T
The term controlled/extended release implies a system that provides continuous delivery of the drug for a predetermined period with predictable and reproducible kinetics and a known mechanism of release. The different mechanisms of drug release in controlled release systems are: Dissolution-controlled release, Osmotic ally controlled release, Diffusion-controlled release, Erosion controlled release and Miscellaneous controlled release. Matrix tablets of metoprolol succinate were prepared by direct compression method with various formulations (F1 to F7).then the tablets were evaluated for physicochemical properties, hardness, weight variation and dissolution rate. Stability studies are also performed for all the formulations, the formulation F6 was found to be suitable. The developed extended release tablet formulation (F6) was quite stable at 400C and 75% RH, with regard to drug content, physical properties and dissolution rate in the accelerated stability studies.
Keywords: Controlled release, Metoprolol, Matrix tablets and weight variation.