Formulation and Evaluation of Metaprolol Succinate Floating Matrix Tablets

¹U. Sambamoorthy^*, ¹D. Yashwant kumar, ²G. Venkata Ramana, ³K.Suresh, ⁴J. Sunil 
¹SARC – (Scientific and Applied Research Center) Hyderabad, India
²Balaji institute of Pharmaceutical sciences, Narsampet, Warangal, Telangana, India
³Pratishta Institute of Pharmaceutical Sciences, Durajpally, Suryapet, Telangana, India
⁴Geetanjali college of Pharmacy, keesara, Hyderabad, Telangana, India

Abstract
Floating drug delivery systems (FDDS) have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system. Metoprolol is a beta₁-selective (cardioselective) adrenergic receptor blocking agent. This preferential effect is not absolute, however, and at higher plasma concentrations, metoprolol also inhibits beta2-adrenoreceptors, chiefly located in the bronchial and vascular musculature. In this investigation metaprolol succinate floating tablets were prepared by using different grades of HPMC Polymers and xanthum gum by direct compression method. The tablets were evaluated for Precompression and post compression parameters indicating that the formulations made considered being satisfactory. In vitro drug release profiles for all formulations were carried out by using 0.1 n Hcl   buffer as dissolution medium for about 12 hrs. From the results it was found that the release of drug from f4 formulation (HPMC k 100M as polymer) gave the better release than other formulations.
Keywords: metaprolol succinate, HPMC K100M, floating drug delivery