Yeduru Krishna Raddy*1, Dr. Shailesh Sharma2
1Pharmaceutical Sciences, NIMS Institute of Phrmacy, NIMS University, Shobhanagar, Jaipur, Rajasthan
2Associate Professor, NIMS Institute of Phrmacy, NIMS University, Shobhanagar, Jaipur, Rajasthan
A B S T R A C T
Inflammation is a common phenomenon involving interrelationships of humoral and cellular reactions through a number of inflammatory mediators. Lornoxicam, a new non-steroidal anti-inflammatory drug with analgesic, anti-inflammatory and antipyretic properties, is also effective in relieving symptoms of osteoarthritis, rheumatoid arthritis, ankylosing and low back pain. SLNs were prepared by o/w Microemulsion technique and characterized by particle size analysis, FTIR spectroscopy, drug entrapment efficiency, SEM, in vitro evaluation studies. In vitro release studies were performed in dissolution cell in phosphate buffer solution of pH 6.8. The kinetics of release was determined and fitted to an empirical equation. The influence of experimental factors such as surfactant concentration, lipid carrier concentration and stirring speed on the nanoparticles size and distribution were investigated to optimize the formulations. At highest speed the resultant SLNs were smaller in size and their size increased with increase in lipid concentration. Smaller size SLNs were obtained with 1 % (1:1 w/v) of lecithin/ tween-80. The in-vitro release was found to follow Non- Fickian Diffusion mechanism. Lornoxicam loaded SLNs can be prepared by microemulsion method with narrow size range, high entrapment efficiency.
Keywords: Solid lipid nanoparticles, Lornoxicam, Triglycerides, particle size, SEM, stability, in-vitro evaluation studies.