Dr. Srinivas Jagarlapudi, A. Ravi Kumar*, Panchumarthi Srinivas, M. Raveendra Babu, Alekhya Jagarlapudi
Obvez Labs Pvt. Ltd. Plot No. 22 & 23, ALEAP Industrial Area, Pragathi Nagar, Hyderabad, Telangana. India- 500090.
A B S T R A C T
Now a day’s, Novel drug delivery system that plays a major role in the delivery of drug to specific site for improve the therapeutic efficiency of drug and to minimize the adverse effects of drug. The therapeutic efficiency of drug is achieved by sustained, extended, controlled and targeting the delivery of the drug to desired site. The aim of the delivery of drug is to assign a therapeutic amount of drug to specific site in the body and then maintain the desired drug concentration of the selected antiretroviral drug like Lamivudine is a BCS class three drug of highly soluble and low permeable. It have short half-life of 5-7 h. The present study is to develop the extended release drug delivery system of Lamivudine with help of various concentrations of polymer combinations to achieve extended release of drug. Lamivudine extended release tablets were successfully prepared and evaluated by using different concentrations of polymer like HPMC K15M, Eudragit RSPO, PEO, HEC, HPMC K100M and Eudragit RLPO in different ratios. HPMC K 15M polymer extended release tablets shows maximum amount of drug release of 100% within 24 h as compared with other polymers. HPMC K15M is hydrophilic polymer that initially showed the burst release of drug from polymer and then retards the drug release by increasing the polymer concentration.
Keywords: Drug delivery, extended release, Lamivudine, polymers, HPMC, Eudragit RSPO