Monday , 13 July 2020

Formulation and evaluation of Fluconazole ophthalmic gel by ion gelation method

B. Syed Salman*1, K. Faizun2
1Department of Pharmaceutics, Mahathi College of Pharmacy, Madanapalle, India.
2Department of Pharmaceutics, P. Rami Reddy Memorial College of Pharmacy, Kadapa, India.

A B S T R A C T
Developed the novel antibacterial drugs with improved efficacy by using different polymers. the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent Fluconazole, based on the concept of ion gelation. In present study Carbopol, 934 and Chitosan were used as polymers. Carbopol 934 was used as a pH sensitive polymer and chitosan as a drug carrier. The prepared formulations were evaluated for pH, clarity, viscosity, drug content, gel strength, in vitro drug release, antibacterial activity, isotonicity test and stability. The formulations were therapeutically efficacious, sterile, stable and provided sustained release of the drug over a period of time.

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