Monday , 18 February 2019

Formulation and Evaluation of Floating and Mucoadhesive Tablet of Oral Hypoglycemic Drug Nateglinide

G. Jagadish*1, Dr. Anil Kumar Middha*2
1Research Scholar, Department of Pharmaceutics, OPJS University, Churu, Rajasthan

2Dr. Anil Kumar Middha, OPJS University, Churu, Rajasthan

In the present research work gastro retentive mucoadhesive floating formulation of Nateglinide by using various hydrophilic polymers. Nateglinide is a drug for the treatment of type 2 diabetes. Initially analytical method development was done for the drug molecule (1-4). Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent accrual and bioadhesive polymer carbopol concentration was optimized. Twelve formulations were developed by using different concentrations of polymers of various polymers. The formulation blend was subjected to various preformualation studies (5-8), flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. The prepared tablets were evaluated, by in-vitro dissolution test results it was found that formulation F12 prepared by using HPMC K15 M and HPMC k 100 M has shown the maximum drug release hence it was considered as the optimized formulation. The optimized formulation dissolution data was subjected to release kinetics (9-10), from the release kinetics data it was evident that the formulation followed zero order kinetics of drug release.
Keywords: Nateglinide, preformualation, hydrophilic polymers

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