Formulation and Evaluation of Famotidine Floating Micro Beads

A. Sai Kiran, K. Prasanna Kumar, K. Sravani, V. Agni, A. Lakshmi Prasanna, T. Kalyani, P. Venkata Madhu Sudhan
Jagan’s College of Pharmacy, Jangala Kandriga (V), Muthukuru (M), Nellore, Andhra Pradesh, India.

ABSTRACT
The main objective of the present study was to prepare and evaluate Floating Micro Beads of Famotidine from the prepared beads by iontotropic gelation method. The FT-IR confirmed that no chemical interaction took place during encapsulation process. The prepared Floating microbeads Surface Morphology were characterized by scanning electron microscopy. The post compressional parameters like the percentage drug content, entrapment efficiency, Percentage Yield, Swelling studies and In vitro dissolution studies. The derived properties like Angle of repose, Hausner’s Ratio, Carr’s Index, Bulk density, tapped density etc., it shows the excellent flow property best formulation is FFMB 8. The swelling Index of Famotidine containing sodium alginate beads FFMB 95.5%. Entrapment efficiency was in range of 98±1.32%. In-vitro release of Famotidine was prolonged release of drug ranges from 95% of Famotidine get released within 2Hour 30 mints. Among the eight formulations the best formulation is FFMB 8. It will follow zero order kinetics of famotidine floating microbeads.
Keywords: Famotidine, Micro beads, ionic gelation, entrapment efficiency.