Formulation and Evaluation of Diclofenac Organogel

Dr. Rajesh Asija*, Ravi Sharma 
Maharishi Arvind Institute of Pharmacy, Jaipur-302020, Rajasthan, India
Received: 27 May 2014, Accepted: 29 June 2014, Published Online: 10 August 2014

Abstract
The main objective of current study is to Formulation and evaluation of diclofenac organogel. diclofenac organogel formulation is optimized and characterized for  pH determination, Measurement of viscosity , Globule size, Drug content study and in-vitro drug release study. Effect of different concentration of Span 80, Tween 80 and Sunflower oil on different properties of organogel formulations  were studied. In this study, we found all the formulations were in pH range of 7.3-7.5 which is similar to the skin pH and can be topically administered easily. OF2 was found pH 7.4. Viscosity of the formulation was found in the optimum range for the gel preparation. Viscosity of OF2 was found 448 cps at 10 rpm, 202 cps at 20 rpm, 119 cps at 50 rpm, 25 cps at 100 rpm. Globule size was found in 88.00 µm- 110.30 µm size range. Globule size of OF2 was found 98.8 ± 12.33 µm. Formulation was optimized on the basis of drug content study and drug release study and was found that formulation containing 4 gm sunflower oil and having ratio of span 80 and tween 80 1:2 gave the best results. Formulation OF2 was found optimized and ideal formulation exhibited 87.07% drug content and 83.34% drug release.
Keywords:  Diclofenac, span 80 , Tween 80 , In- vitro drug release.