Formulation and Evaluation of Chitosan Based Hydrogel Beads for Controlled Release of Ketorolac Tromethamine

Hyma.P*, Dileep Akula
Scientific and Applied Research Center, Hyderabad., India

A B S T R A C T
The present work deals with the formulation and evaluation of particulate drug delivery systems for the controlled release of ketorolac. The main objective of any drug therapy is to achieve a desire concentration of drug in blood or tissue, which is therapeutically effective and non toxic for an extended period of time. Oral controlled release multi-particulate dosage forms such as beads, pellets and micro particles are becoming more popular than single unit dosage forms. These systems tend to spread uniformly throughout the gastro-intestinal tract -GIT. In this present investigation Ketorolac tromethamine was formulated into controlled release micro beads with three different polymers (Sodium alginate, HPMC, Eudragit RSPO) each at two different ratios. The beads were prepared by ionotropic cross linking method, using TPP as cross linking agent and the prepared beads were evaluated for surface morphology, bead size, entrapment efficiency, fourier transform infrared spectroscopy, differential scanning calorimetric, dynamic swelling, in vitro drug release, stability studies. Out of all the polymers used beads made of sodium alginate at higher ratio showed significant results than other polymers used. Micro beads prepared using sodium alginate showed better entrapment efficiency, swelling index and improved in-vitro drug release compared to other two polymers used.
Keywords: Multiparticulate system, Controlled delivery, Ketorolac tromethamine, Beads.