Mallikarjun Vasam*1, Dr. S.N. Sri Harsha1, P. Hyma2, D. Yashwanth Kumar2
1Pacific University, Udaipur, Rajasthan, India
2SARC (Scientific and Applied Research Center), Hyderabad, India
A B S T R A C T
Microspheres of cefixime were prepared using the solvent evaporation method. The effect of different factor such as concentration of ethyl cellulose (polymer) on the characteristics of the microspheres was investigated. The morphology of microspheres was studied using optical and scanning electron microscopy and it was shown that microspheres had a spherical shape and slightly ellipsoidal. The particle size of microspheres analyzed by optical microscopic method was affected by concentrations of ethyl cellulose. When drug to polymer ratio was increased from 1:1 to 1:6, the proportion of larger particles formed became higher, which may be due to increase in viscosity of the solvent with increase in polymer to drug ratio. Larger microspheres showed greater drug loading. For formulation with drug: ethyl cellulose ratio 1:3 (batch M3) drug release was optimum. It revealed that increase in concentration of ethyl cellulose decreases the drug diffusion from microsphere.
Keywords: Cefixime, Ethyl Cellulose, Microspheres, SEM