Formulation and Evaluation of Atorvastatin Floating Tablets

G. Gangadhara*,   I. Sarath Chandran, Armugaraja, Ch. Praveen Kumar, K. Gnanaprakash, M. Gobinath, R. Subramanan.
Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, SPSR Nellore, A.P, India

A B S T R A C T
The aim of present study is to formulate and evaluate atorvastatin floating tablets using three different polymers such as HPMC, microcristaline cellulose, magnesium stearate, Atorvastatin is an histamine H2-receptor antagonist drug used against peptic ulcer disease and gastroesophagal reflux To development analytical method for the estimation of selected drug by UV double beam spectrophotometer. Success of the invitro drug release studies recommends the product for further in vivo studies, which may improve patient compliance. From the results, formulation F9 containing Atorvastatin40 mg, Guar gum 60 mg and NaHCO₃ 35 mg evolved as the optimized formulation and it releases more than 90% drug in 12hrs. Short-term stability studies of optimized formulation F9 indicate, that there are no significant changes in drug content and dissolution parameter values after 3 weeks storage at 45±1ºC. IR spectroscopic studies indicated that there is no drug-excipient interaction in the optimized formulation. The optimized formulation F9 can be considered as a promising gastro-retentive drug delivery system of Atorvastatin providing nearly zero order drug release over a period of 12 hrs.
Keywords: Atorvastatin, HPMC, H2 Receptor, magnesium stearate, microcristalline cellulose