Wednesday , 20 September 2017

Formulation and Evaluation of a Novel Microemulsions of Atorvastatin Calcium Trihydrate

Hyma .P*, Yashwanth kumar.D
Scientific and Applied Research Center, Hyderabad, Telangana, India

A B S T R A C T
The objective of the present study was to prepare and evaluate Hydrogel Beads for the controlled release of Nizatidine from the prepared Hydrogel beads using different polymers. The Hydrogel beads were prepared by ionotropic gelation method. The prepared Hydrogel beads were characterized for FTIR, scanning electron microscopy (SEM), the percentage drug content, entrapment efficiency, in vitro dissolution studies, Release order kinetics, Stability studies. The Particle size of hydrogel beads was determined with the help of SEM and it was found to be ranging from 500-650 µm. The swelling Index of Nizatidine containing Hydrogel beads F 11 formulation contains the value 28 ±1 %. The FT-IR and DSC study confirmed that no chemical interaction took place during encapsulation process. Entrapment efficiency was in range of all formulation 76.2-77.3%. The drug entrapment of various batches varied from 47.35% to 99.68%. The F11 formulation observed a zero order release based on the regression coefficient value in kinetics study.
Keywords: PEG 400, Cremophor RH40, Ternary phase diagrams, Zeta potential.

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