Navneet Kumar Verma*, P.D. Panda, Wajahat Ullah Khan, Priyanka Agrahari, Somika Singh
Asst. Professor, Kailash Institute of Pharmacy and Management, GIDA, Gorakhpur, U.P, India
A B S T R A C T
Floating drug delivery systems (FDDS) or hydrodynamically controlled systems are low-density systems that have sufficient buoyancy to float over the gastric contents and remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system. After release of drug, the residual system is emptied from the stomach. This results in an increased GRT and a better control of the fluctuations in plasma drug concentration. However, besides a minimal gastric content needed to allow the proper achievement of the buoyancy retention principle, a minimal level of floating force (F) is also required to keep the dosage form reliably buoyant on the surface of the meal. Many buoyant systems have been developed based on granules, powders, capsules, tablets, laminated films and hollow microspheres. Evaluation of blend powder and floating tablets are explained. Marketed formulations and recent advances in FDDS are also reviewed in this article.
Keywords: FDDS, Buoyancy, Gastric emptying rate, Gastric content.