Dept. of Pharmacology, Saastra College of Pharmaceutical Education and Research, Nellore, A.P, India
It is a rarest and most severe genetic disabling disease which may effect on the muscles and leads to irreversible muscle to bone termination, which may cause a worse body shape of human body. This disorder was affects 1 out of 2000000 people, around 3500 people are affected till now throughout the world. In that 850 cases are disposed. It’s an impulsive and post traumatic flare-ups shown by intense connective tissue edema with perivascular lymphocytic penetration into skeletal muscle. Angiogenic fibopriline ferative lesions. Surgery makes the condition worse Formation of FOP bones is only occurs before the age of 10. Bone surgery and opiods are the common treatments.
Keywords: Fibrodysplasia ossificans progressiva, connective tissue, flare-ups, ACVR1 gene