Monday , 27 March 2017

Ferric chloride immobilized on neutral alumina: an efficient catalyst for the solvent-free selective synthesis of 1, 2-disubstituted benzimidazoles

M. Hari Krishna, P. Thriveni*
Department of Chemistry, Vikrama Simhapuri University, Nellore-524003, Andhra Pradesh, India.

A B S T R A C T
Synthesis of 1,2-disubstituted benzimidazoles from o-phenylenediamine and aromatic aldehydes in an excellent yield (86-95%)in presence of FeCl3–Al2O3 using microwave (MW) irradiation under solvent-free conditions. The present protocol shows some specific advantages such as mildness, short reaction times and enhanced selectivity under solvent-free conditions.
Keywords: Benzimidazoles, microwave assisted synthesis, Lewis acid

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