M. Hari Krishna, P. Thriveni*
Department of Chemistry, Vikrama Simhapuri University, Nellore-524003, Andhra Pradesh, India.
A B S T R A C T
Synthesis of 1,2-disubstituted benzimidazoles from o-phenylenediamine and aromatic aldehydes in an excellent yield (86-95%)in presence of FeCl3–Al2O3 using microwave (MW) irradiation under solvent-free conditions. The present protocol shows some specific advantages such as mildness, short reaction times and enhanced selectivity under solvent-free conditions.
Keywords: Benzimidazoles, microwave assisted synthesis, Lewis acid