Fabrication and Evaluation of Montelukastsodium Sustained Release Matrix Tablets Using Hibiscusrosa-sinensis Leaves Mucilage

Ramesh Naik M*, Hindustan Abdul Ahad, Ishaq B Md 
PG Department of Pharmaceutics, Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India
APOTHEKE-2014, 8 Nov 2014, Organized by Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India

Abstract
The main target of the present investigation was to prepare Montelukast sodium matrix tablets by using Hibiscus rosa-sinensis leaves mucilage for its release retardant bustle. Hibiscus rosa-sinensis leaves were characterized for physicochemical assets. Diverse matrix tablets were prepared by wet granulation technique. The prepared matrix tablets found to have good pre-compression and post compression parameters. The swelling performance, release rate features and the in vitro dissolution study displayed that the dried Hibiscus rosa-sinensis leaves mucilage can be used as a matrix former in tablets. The drug release kinetics from optimized F-5 formulation showed zero order release. The study concludes that Hibiscus rosa-sinensis leaves mucilage can be used as aproficient matrix forming polymer, to retard the release of Montelukast from the tablets.
Keywords: Montelukast sodium, Hibiscus rosa-sinensis, matrix tablets, sustained release