Monday , 3 August 2020

Evaluation of Protective Potential of Nyctanthus Arbor Tristis against Chloform induced Hepatptoxicity in Rats

About author
Sonu Sharma*, Seema Gupta, Ayaz Ahmad
Nims Institute of  Pharmacy, Nims University, Shobha Nagar , Jaipur, Rajasthan, India
Gyan Vihar School of pharmacy, Suresh Gyan Vihar University, Rajasthan, India
E-mail: sonu.sharma283@gmail.com

Abstracts:
Nyctanthes arbor-tristis Linn family Nyctantheaceae is widely distributed and easily available in the nature, therapeutic use of this plant is detailed in Charaka samhitha, Sushrutha samhita and other traditional systems of medicine. The seeds are cooling and astringent and are useful in vitiated condition of pitta. Seeds are useful in bilious disorders, yield fatty oil used as an illuminant. Oil from seed is used for poisonous bites, bowel complaints, epilepsy and for blackening the hair. Bark has expectorant activity and has the power of removing pains and aches. The drug is also used as Hepatoprotective. The dried leaves was subjected to successive extraction using different solvent such as petroleum ether, chloroform, ethyl acetate, and methanol. These solvent extracts were subjected to a Phytochemical evaluation to detect the different chemical principle present i.e. Carbohydrates, Protein, Amino acids, Steroids, Glycosides, Alkaloids, Tannins, and Phenolic compounds and to carry out Chromatographic evaluation to isolate the chemical compounds. The present study was aimed at Chromatographic evaluation of Nyctanthes arbor-tristis Linn leaves. Methanol, Petroleum ether extract of leaves of Nyctanthes arbor-tristis Linn was screened in-vivo Hepatoprotective investigations. The Hepatoprotective activity of the various extracts of bark of Nyctanthes arbor – tristis Linn. Was evaluated by the carbon tetra chloride method. In-vivo screening hepatoprotective shows significant activity in ethanolic extract of 100mg/kg and 200mg/kg dose when compared with standard hepatoprotective drug silymarin.
Key words: Chromatography, Hepatoprotective, Expectorant, investigation

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