Tuesday , 12 November 2019

Evaluation of Hepatoprotective activity of Delonix Elata against Carbontetra chloride, Paracetamol and ethanol induced Hepatotoxicity in rats

P. Sripal Reddy*¹, M. Raghavendra¹, M. Venkata Kirankumar¹, K. Abbulu²
¹Dept. of Pharmacology, CMR College of Pharmacy, Kandlakoya, Medchal Road, Hyderabad-501401, Telangana, India.
¹Associate Professor, Department of Pharmacology, CMR College of Pharmacy, Kandlakoya, Medchal Road, Hyderabad-501401, Telangana, India.
¹HOD, Department of Pharmacology, CMR College of Pharmacy, Kandlakoya, Medchal Road, Hyderabad-501401, Telangana, India.
²Principal, Department of Pharmaceutics, CMR College of Pharmacy, Kandlakoya, Medchal Road, Hyderabad-501401, Telangana, India.

A B S T R A C T
Herbal drugs play a vital role in the management of various liver disorder, most of them speed up the natural healing process of liver. Numerous medicinal plants and their formulations are used in liver disorders in ethno medicinal practices as well as traditional system of medicine in India.The present work deals with hepatoprotective activity of ethanolic extract of Leaves Delonix Elata (L)against carbon tetrachloride, ethyl alcohol and paracetamol induced liver damage in rats. Delonix Elata produce various pharmacological activities such as aphrodisiac, immunostimulant, hepatoprotective, antioxidant, anticancer and anti-diabetic activities. Liver can participates in a variety of metabolic activity by the presence of no of enzymes and them self-exposed too many toxicants, drugs, chemicals which can damage it. In this Hepatoprotective study, carbon tetra chloride, paracetamol and ethanol are used as hepatotoxic agents to induce liver damage, since it is used by human being for non-medical purposes or by medical purposes. In the present study, the extracts significantly reduced the elevated levels of above mentioned serum marker enzymes and increase in the levels of protein. Hence, at this point it is concluded that the extracts possess hepatoprotectve activity.
Keywords: Medicinal plants, Delonix Elata, Ethanolic extract, Hepatoprotective, Carbontetra chloride, Paracetamol

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