Gampa Vijaya Kumar1, Dr. Y. Sridhar2, M.Anitha3
1Professor and Head, Department of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
2Professor, KGR Institute of Technology and Management, Kesara, Rangareddy, Telangana, India.
3KGR Institute of Technology and Management, Kesara, Rangareddy, Telangana, India.
Hepatotoxicity may be predictable or unpredictable. Predictable reactions typically are dose related and occur which are exposed shortly after some threshold for toxicity is reached. Chemicals such as carbon tetrachloride, phosphorus, and chloroform fairly predictablehepatotoxins that are no longer used as drugs. Unpredictable hepatotoxic reactions occur without warning, are unrelated to dose, and have variable latency periods, ranging from a few days to 12 months.Liver injury is defined as an alanine aminotransferase (ALT) level of more than three times the upper limit of the normal range, an alkaline phosphatase (ALP) level of more than twice the upper limit of normal, or a total bilirubin (TB) level of more than twice the upper limit of normal if associated with any elevation of the alanine aminotransferase or alkaline phosphatase level. Liver injury is further characterized as hepatocellular when there is a predominant initial elevation of the alanine aminotransferase level or as cholestatic when there is a predominant initial elevation of the alkaline phosphatase level a mixed pattern comprises elevations of both the alanine aminotransferase and alkaline phosphatase levels. Recognizing the pattern of liver injury helps to categorize it, since drugs tend to create injury predominantly in one or another pattern. The injury patterns are not mutually exclusive, and a mixed pattern of injury may occur in many instances of drug-related hepatotoxicity.
Keywords: basellarubra, hepatotoxicity, alanine aminotransferase