1Varukolu Soundarya*, 2Chintala Swetha Bindu, 3Dr. Challa Pradeep Kumar, 4Porandla Ravali
Department of Pharmacology, Vaageswari College of Pharmacy, Karimnagar, Telangana 505001.
A B S T R A C T
The present study was aimed at evaluating the hepatoprotective activity of Bauhinia acuminata.L against Carbon tetra chloride induced hepatotoxicity in rats. Hepatic damage was induced by administration of CCL4 (1.5ml/kg b.w, i.p) in combination with olive oil (1:1) as a single dose. The extent of liver damage was studied by measuring liver tissue damage markers like SGOT, SGPT, ALP & BILIRUBIN (TOTAL & DIRECT) levels. Bauhinia acuminata.L showed the hepatoprotective activity by lowering CCL4 induced elevation of SGOT, SGPT, ALP & BILIRUBIN levels (p<0.01) and was confirmed by the histopathological examination of liver tissues treated with test compound. This result strongly supports the protective effect of EEBA against liver injury.
Keywords: Bauhinia acuminata.L, Hepatoprotective, CCl4, Silymarin, Hepatotoxicity.