M. Lakshmi, B. Kumar*, P. Naresh Babu
Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh, India
A B S T R A C T
Intake of diets rich in antioxidant from medicinal plants have been reported to be associated with reduced risk of cardiovascular diseases. The present study was aimed to appraise the protective role of Cordia sebestinato leaf extract in isoproterenol-induced myocardial infarction in rats. Subcutaneous injection of isoproterenol (85 mg/kg) to male albino Wistar rats, exhibited a significant raise in the levels/activities of cardiac marker such as The present study reveals that ISO treatment resulted inmarked elevation in the level of cardiac marker enzymeslike CK-MB, AST, ALT, LDH and ALP in serum, serum lipid profiles such as HDL, LDL, VLDL, TGA, and Cholesterol are observed such that there is marked decrease in the levels of HDL in ISO treated group was observed. Pretreatment with Cordia sebestinato (200 and 400 mg/kg) daily for a period of 31days positively altered the activities of cardiac markers and other biochemical parameters to isoproterenol-induced rats. Thus, the results of our study demonstrate that Cordia sebestinato possess cardioprotective role against experimentally induced cardiac toxicity.
Keywords: HDL, LDL, VLDL, TGA, Wistar rats