Sivanandam*, C. Prdeep Kumar
Department of Pharmacology, Teegala Krishna Reddy College of Pharmacy, Meerpet, Saroornagar, Hyderbad-500 097.
A B S T R A C T
The cause of ulceration in patients is mainly due to hyper secretion of gastric juice and also due to hyper secretion of pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. There are various medicinal plants has been used for the treatment of gastrointestinal disorders. In view of this, in present study we have to evaluate the anti-ulcer activity of Ziziphusjujuba. Study was carried out, by using two methods i.e., alcohol and paracetamol induced ulcers with the doses of 250 mg/kg AQEZJ and ALEZJ, 20mg/kg Omeprazole and 50 mg/kg Ranitidine through oral administration. In alcohol-induced ulcers, AQEZJ and ALEZJ were effective in reducing lesion index and increasing the gastric mucus content. It was also effective in decreasing ulcer index in paracetamol-induced ulcers. All the results obtained with ZJE were dose dependent. The results suggest that AQEZJ and ALEZJ possesses significant and dose dependent antiulcer activity. The antiulcer activity of AQEZJ and ALEZJ can be attributed to its cytoprotective and anti-secretary action.
Keywords: Ziziphusjujuba, anti-secretary, cytoprotective, gastric ulcer, alcohol induced ulcers, paracetamol-induced ulcers and stress induced ulcers.