Friday , 19 April 2019

Evaluation of Anti-Ulcer Activity Lagenaria Siceraria Chloroform Extracts in Pylorus Ligated Rats

Dr. Gampa Vijay Kumar1*, Dr. Y. Sridhar2, M. Prashanth3
1Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.

2Professor KGR Institute of Technology and Management, Kesara, Rangareddy, Telangana, India.
3KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.

A B S T R A C T
Peptic ulcer disease is a serious gastrointestinal disorder that requires well targeted therapeutic strategy. A number of drugs including proton pump inhibitors and H2 receptor antagonists are available for the treatment of peptic ulcer, but clinical evaluation of these drugs has shown incidence of relapse, side effects and drug interactions. This has been rational for the development of new anti-ulcer drugs and search for novel molecules has been extended to herbal that offer better protection and relapse.  The present study is to evaluate the anti-ulcer activity by using herbal remedy lagenaria siceria. The ethanolic extract of lagenaria siceria treated groups shows a significant effect when compared to control group animals which indicating that the plant having the anti-ulcer activity. The acute toxicity study conducted for ethanolic extract of lagenaria siceria indicates that safe up to 2000mg/kg body weight. Ulcer can minimize by some life style changes like, avoid eating at least two hours before bed time and whatever foods might cause discomfort, such as alcohol, caffeine beverages (coffee and pop), fatty foods, and highly seasoned foods. It is important to try to stop smoking, since smoking has been linked to ulcer formation, reduced healing, and ulcer recurrences. Also try to minimize stress in life.  Stress may worsen ulcer symptoms.
Keywords: Lagenaria siceria, Anti-Ulcer, Ethanolic.

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