Shravan Kumar Nanumala*1, K. Ram prasad2, E. Sujitha3
1Department of Pharmacology, Joginpally B.R. Pharmacy College, Hyderabad, India.
2Department of Pharmacology, Sree Chaitanya Institute of Pharmaceutical Science, Karimnagar, Telangana.
3Department of Pharmacology, Jyothishmathi institute of pharmaceutical science, Karimnagar, Telangana.
A B S T R A C T
The aim of this study was to investigate anticonvulsant effect of Cassia angustifolia on Maximal electroshock-induced seizures (MES) and Pentylenetetrazole (PTZ) induced seizures. The ethanolic seed extract of Cassia angustifolia (100,200,400 mg/kg. p.o.) were studied for their anticonvulsant effect on MES and PTZ induced seizures in rats. The onset and duration of Hind Limb Tonic Extension were noted. The ethanolic seed extract of Cassia angustifolia significantly abolished the hind limb tonic extension in MES and PTZ method. The 400mg/kg dose more significantly (p<0.001) protected the animals from induced tonic convulsions. The data suggests that the ethanolic seed extracts of Cassia angustifolia may produce its anticonvulsant effects via non-specific mechanisms since it abolished the hind limb tonic extension induced by MES as well as PTZ method.
Keywords: Cassia angustifolia, Pentylene tetratriazole, Maximal electroshock, Ethanolic extract, anti-epileptic.