Salma Begum*, Airaj Mahajabeen, Rubina Kauser, Farhana Shaheen, Syed Sajid Ali
MRM College of Pharmacy, Chintapalliguda, Ibrahimpatnam, R.R District-501510
A B S T R A C T
The dry leaves of Pongamia pinnata Linn. is used in traditional medicines for the treatment of diarrhoea, diabetes and inflammatory disorder. In the present study, we investigated the analgesic activity of the standardized hydroalcoholic extract was evaluated for its in-vivo analgesic activity by using the Eddy’s Hot plate method in wistar rats. In both of the cases Diclofenac sodium was used as standard drug. The extract at the doses of 200 and 400 mg/kg elicited a significant analgesic activity in a dose-dependent manner by using Eddy’s Hot plate method. The analgesic mechanism of activity of the standardized hydro alcoholic extract of P. Pinnata Linn. pain mediators may be the main mechanisms of action of P. Pinnata hydro alcoholic extract.
Keywords: Pongamia pinnata, analgesic, hydroalcoholic extract