Efficacy of morin on ethanol-induced oxidative stress in rat intestine

ABOUT AUTHOR
S. Anbu, N. Saravanan*
²Lecturer, Division of Biochemistry, Rani Meyyammai College of Nursing, Annamalai University, Annamalai Nagar -608002                   
¹Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar-608002, Tamil Nadu, India

Abstract: Ethanol is known to induce oxidative stress in the intestine and initiates gastrointestinal tract disorders. This study was evaluated the protective effect of morin on ethanol-induced oxidative stress in the intestine of rats. Administering ethanol (6 g/ kg BW)  to rats for the period of 60 days resulted in significant elevated levels of intestinal lipid peroxidation by products such as thiobarbituric acid reactive substance (TBARS), lipid hydro peroxide (LOOH) and lipid levels (Cholesterol, Triglycerides, Phospholipids and Free Fatty acid). Moreover ethanol-fed rats showed lowered activities/level of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and reduced glutathione (GSH) as compared with those of normal control rats. Ethanol fed rats treated with morin (60mg/kg BW) daily for a period post 30 days significantly (p < 0.05) modulates the  enzymic antioxidants, reduced lipid peroxidation and  lipid levels  as compared to untreated ethanol fed rats. In conclusion, morin can effectively protected the intestine against ethanol-induced oxidative stress by directly enhancing the levels of endogenous antioxidants, reducing the levels of lipid peroxidation and lipids.
Key words: Ethanol, Gastrointestinal tract, Morin, Antioxidants