Friday , 14 December 2018

Effect of Polymers on Amoxicillin Release from Matrix Tablets

B. Deepika*1, Sobana Sameen1, Nazneen1, A. Madhavi1, Kandukoori Naga Raju1, S. Saroini2, A. Thanga Thirupathi 3 , KNV Rao4, K. Rajeswar Dutt5
1Department of Pharmaceutics, Nalanda College of Pharmacy, Nalgonda, T.S-508001
2Department of Industrial Pharmacy, Nalanda College of Pharmacy,   Nalgonda, T.S-508001.
3Department of Pharmacology, Nalanda College of Pharmacy, Nalgonda, T.S-508001.
4Department of Pharmacognosy, Nalanda College of Pharmacy, Nalgonda, T.S-508001.
5Department of Pharmaceutical Analysis, Nalanda College of Pharmacy, Nalgonda, T.S- 508001

ABSTRACT
Sustained Release Matrix Tablets of Amoxicillin were prepared by using Different Rate controlling polymers like Sodium Alginate, Chitosan, Guar Gum and Eudragit L100. Developed total four formulations by using Direct Compression method. The prepared sustained release matrix tablets were evaluated for different evaluation tests like weight variation, Hardness, thickness, friability, Content Uniformity and In-vitro release studies. Out of all the four formulations F4 containing eudragit L 100 showed 100 % drug release within 10 hours with sustained. So, Eudragit L100 was selected as best formulation based on the evaluation tests20.

Keywords: Matrix tablets, sustained release dosage forms, Amoxicillin, Eudragit L100.

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