Effect of Hydroalcoholic Extract of Orthosiphon Thymiflorus Leaves on Glycemia of Diabetic Rats

Riyazunnisa D^*1, Sultan Ali², Karimulla Shaik^3
1Dept. of Pharmacology, Sri Lakshmi Venkateswara Institute of Pharmaceutical Sciences, Proddatur, A.P, India -517132
²Dept. of Pharmacology, SAFA College of Pharmacy, Thandrapadu, Kurnool, A.P, India -518007
³Dept. of Pharmacology, Narayana Pharmacy College, Chintareddypalem, Nellore, A.P, India -524003

A B S T R A C T
The present study was aimed to investigate the antihyperglcemic activity of hydroalcoholic extract of Orthosiphon thymiflorus leaves (HAEOT) on high fat diet (HFD) – streptozotocin (STZ) induced diabetic rats. Male wistar albino rats were fed with a high fat diet for a period of two weeks prior to the administration of streptozotocin (50mg/kg) intraperitonially. The long term effect of the extract was studied by treating diabetic rats with vehicle (0.5% CMC) and HAEOT (200 and 400 mg/kg b wt) for a period of 28 days. The effects of HAEOT on fasting blood glucose and serum insulin levels were studied. In addition, body weight changes, lipid profile and serum biomarkers of liver and kidney function were also studied. Results revealed that HAEOT-400mg shows excellent anti hyperglycemic activity when compared to lower dose of the extract 200mg and also shows better anti hyperlipidemic activity. The elevated serum urea and creatinine levels also decreased by the treatment with extract. Hence the results justify that Orthosiphon thymiflorus possess antidiabetic activity.
Keywords: Orthosiphon thymiflorus; Anti-diabetic activity; Streptozotocin