Monday , 20 January 2020

Development and Validation of Estimation of Lafutidine by Spectroscopic Method in Tablet Dosage Form

1Ms. Heta Shah*, 2Ms. Archita Patel, 3Ms. Advaita Patel
1Department of Pharmaceutical Chemistry, Saraswati Institute of Pharmaceutical Sciences, Gandhinagar, India
2Department of Pharmaceutical Chemistry, K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, India
3Department of Pharmaceutical Chemistry, Kalol Institute of Pharmacy, Kalol, India

A B S T R A C T
Spectroscopic estimation of Lafutidine in bulk and tablet was developed and validated. Methanol was used as a solvent for analysis. Detection was carried out at 273 nm for Lafutidine. Linearity was observed at concentration range 10-80 µg/ml. Correlation coefficient for Lafutidine was found 0.9975. The method was found to be Simple, Sensitive, Accurate and Precise as per ICH guideline Q2B(R1). The method can successfully applicable to routine analysis.
Keywords: Lafutidine, Methanol, UV spectrophotometry

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