Monday , 29 May 2017

Development and In-vitro Characterization of Gastro Retentive Floating Tablets of Nefidipine Using Various Polymers

B. Sindhura1, Gampa Vijaya Kumar*2, Vijay Prakash3, K. Someshwar4
1CVM college of Pharmacy, Karimnagar, Telangana, India
2Professor & Principal, CVM college of Pharmacy, Karimnagar, Telangana, India
3Assistant professor, CVM college of Pharmacy, Karimnagar, Telangana, India
4Managers, Formulation R&D, KP Labs (A Division of KDPL), Kothapet, Hyderabad, Telangana, India 

A B S T R A C T
The aim of the present study was to develop sustained release formulation of Nifedipine to maintain constant therapeutic levels of the drug for over 12 hrs. Various natural polymers such as Guar gum Sodium CMC and Chitosan were employed as polymers. Nifedipine dose was fixed as 50 mg. Total weight of the tablet was considered as 300 mg. Polymers were used in the concentration of 60, 90 and 180 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F3) showed better and desired drug release pattern i.e., 97.30 % in 12 hours. It followed zero order release kinetics mechanism.
Keywords: Nifedipine, Guar gum, Chitosan, Sodium CMC and sustained release tablets.

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