Balachandrudu*, Somasekhar.G, Nazemoon.R, Raziya SMD.
Department of Pharmaceutics, Safa College of Pharmacy, Kurnool, Andhra Pradesh, India
A B S T R A C T
Carvedilol is a poorly water soluble oral antihypertensive agent. An attempt has been made to develop fast dissolving the tablet of carvedilol by direct compression and solid dispersion technique the solid dispersion of carvedilol with peg-4000(1:4 molar ratio) by fusion extrusion method with a view to enhance the water solubility. The fast dissolving tablets were prepared using different concentrations of super disintegrants such as cross carmellose, sodium starch glycolate, cross povidone, the formulations were evaluated for physicho-chemical parameters, subjected to disintegration and dissolution test. When super disintegrating agents were added in one formulation, an increase in the disintegration time and in-vitro cumulative percent drug dissolution was observed.
Keywords: Fast disintegrating tablet, Super disintegrants, Carvedilol, Solid dispersion.