Hyma.P*, Yashwanth kumar .D, Shiva Prasad
Scientific and Applied Research Center, Hyderabad, Telangana, India
A B S T R A C T
The purpose of this research was to prepare a floating drug delivery of abacavir sulphate in order to increase the gastric residence time (GRT) and comparison of two different natural polymers for better sustained effect. The tablets were prepared by direct compression. The pre and post compression studies were performed. The release behavior of the two different natural polymers (was compared) according to the obtained data. Formulations F1 to F8 contained xantahan gum and F9 to F16 contained chitosan. F4 has shown 75% of drug release in 12 hrs and F11 has shown 83% in 12hrs. The formulation with chitosan shows better sustained effect than xanthan gum. Te developed floating tablets of abacavir sulphate may be used for prolonged drug release for atleast 12hrs, thereby improving the bioavailability and patient compliance.
Keywords: Abacavir suphate, sustained release, chitosan, prolonged release.