Sunday , 22 October 2017

Determination of Febuxostat by Complexation with Mercury (Hg II) Ions Using Spectrophotometry

G. Somasekhar*, P. Mamatha, S. Nirosha rani, N. Raja Kumar, S. Ismail Zabiullah, M. Mahaboob Basha
Department of Pharmaceutical Chemistry, Safa College of pharmacy, Dupadu, Kurnool, A.P. India

A B S T R A C T
A simple, sensitive and accurate Colorimetric method was described for the determination of Febuxostat (FBX) an antigout drug. The method is based on yellow coloured chelate formation between [FBX and Mercury (HgII)] in alkaline medium. The complex showed an absorption maximum at 510nm with apparent molar absorpitivity of 4.62×10 4 L-M-1Cm1.The solution of the complex obeyed beer’s law in the concentration range of 5-30  . The limit of detection and Limit of quantification were calculated and RSD were calculated. The chelate composition between [FBX and Hg (II)] ion was found to be 2:1 ratio determined by Job’s continuous method and by Molar ratio method. The proposed method was applied for the determination of FBX in tablets without interference from common excipients. The results obtained by the application of this procedure showed percentage recoveries were 99.8±0.15.
Keywords: Febuxostat, Chelate, Alkaline media, Colorimetric

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