M. Divya1*, M. Kiranmai1, G. Vijaya Reddy1, G. Kalpana Devi2
1Sai Pranavi College of Pharmacy, Keesara, R.R. Dist., Telangana, India
2Assistant Professor, Sai Pranavi College of Pharmacy, Keesara, R.R. Dist., Telangana, India
A B S T R A C T
In the present research work sustained release matrix, formulation of Doxofylline targeted to colon by using various polymers developed. To achieve pH-independent drug release of Doxofylline, pH-modifying agents were used. Colon targeted tablets were preparedin two steps. Initially core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethyl cellulose, Eudragit L100 and S100 were used as enteric coating polymers. The pre-compression blend of all formulations was subjected to various flow property tests and all the formulations were passed the tests. Among all the formulations F3 formulation was found to be optimized as it was retarded the drug release up to 12 hours and showed maximum of 98.69% drug release. It followed zero order kinetics mechanism.
Keywords: Doxofylline, Colon targeteddrug delivery system, Ethyl cellulose, Eudragit L100, Eudragit S 100.